Directions from Route 22
If you approach from Route 22, take the South Bethlehem/Route 378 exit. Continue for 3.6 miles to the point where you cross the bridge over the Lehigh River. Stay in the right lane over the bridge.
At the traffic light at the end of the bridge, turn right onto Third Street. Third Street becomes Delaware Avenue. Continue on Delaware Avenue to the next traffic light.
Turn right onto St. Luke's Place. At this point, the hospital is directly in front of you. Follow the signs for the St. Luke's School of Nursing – Trexler Building.
Directions from I-78
If you approach from I-78 W, take exit 67 (Hellertown). Turn right onto Route 412 N. After traveling 1.8 miles, you will come to a traffic light at a small bridge. Bear to the right, following the Route 412 N signs. You will pass the former Bethlehem Steel plant on your right and then travel through a small business district (Route 412 at this point is Third Street).
Continue straight ahead on Third Street, crossing the intersection of West Third Street and Wyandotte Street (Route 378). Shortly before coming to the next traffic light, you will notice that West Third Street becomes Delaware Avenue. At the traffic light, turn right at St. Luke's Place. The hospital is directly in front of you. Follow the signs for the St. Luke's School of Nursing – Trexler Building.